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OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis

Identifieur interne : 009438 ( Main/Exploration ); précédent : 009437; suivant : 009439

OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis

Auteurs : Laure Gossec [France, Canada, Suède, États-Unis, Royaume-Uni, Australie, République tchèque, Italie] ; Gillian Hawker [France, Canada] ; Aileen M. Davis [Canada] ; Jean Francis Maillefert [France] ; L. Stefan Lohmander ; Roy Altman ; Jolanda Cibere ; Philip G. Conaghan ; Marc C. Hochberg ; Joanne M. Jordan ; Jeffrey N. Katz ; Lyn March ; Nizar Mahomed ; Karel Pavelka ; Ewa M. Roos ; Maria E. Suarez-Almazor ; Gustavo Zanoli ; Maxime Dougados

Source :

RBID : Pascal:07-0314512

Descripteurs français

English descriptors

Abstract

Objective. Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee, and to create a composite measure of these 3 domains to define states of OA severity and a surrogate measure of "need for joint replacement surgery." Methods. For pain, focus groups and one-on-one interviews were used. For function, Rasch analysis was performed on existing indices - the Hip Dysfunction and Osteoarthritis Outcome Score (HOOS) and the Knee injury and Osteoarthritis Outcome Score (KOOS), each of which subsumes the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questions. For structure, a comparison of existing indices (Kellgren-Lawrence, OARSI stages, and joint space width) was performed for the hip and the knee. Results. For pain, key features of pain that are most distressing to people with OA from early to late disease were identified. For function, the reduction of the number of items based on the existing indices continues. For structure, the analysis is also ongoing. Conclusion. Preliminary results were presented at OMERACT 8; the final objective will be to combine the 3 domains (pain, function, and structure) and to create a composite index that could define states of severity and "need for total joint replacement," which could be used to evaluate treatment response to disease-modifying drugs in OA clinical trials.


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Le document en format XML

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<name sortKey="Maillefert, Jean Francis" sort="Maillefert, Jean Francis" uniqKey="Maillefert J" first="Jean Francis" last="Maillefert">Jean Francis Maillefert</name>
<affiliation wicri:level="3">
<inist:fA14 i1="05">
<s1>Dijon University Hospital, and INSERM ERM 0207, University of Burgundy</s1>
<s2>Dijon</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName>
<region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Bourgogne</region>
<settlement type="city">Dijon</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lohmander, L Stefan" sort="Lohmander, L Stefan" uniqKey="Lohmander L" first="L. Stefan" last="Lohmander">L. Stefan Lohmander</name>
</author>
<author>
<name sortKey="Altman, Roy" sort="Altman, Roy" uniqKey="Altman R" first="Roy" last="Altman">Roy Altman</name>
</author>
<author>
<name sortKey="Cibere, Jolanda" sort="Cibere, Jolanda" uniqKey="Cibere J" first="Jolanda" last="Cibere">Jolanda Cibere</name>
</author>
<author>
<name sortKey="Conaghan, Philip G" sort="Conaghan, Philip G" uniqKey="Conaghan P" first="Philip G." last="Conaghan">Philip G. Conaghan</name>
</author>
<author>
<name sortKey="Hochberg, Marc C" sort="Hochberg, Marc C" uniqKey="Hochberg M" first="Marc C." last="Hochberg">Marc C. Hochberg</name>
</author>
<author>
<name sortKey="Jordan, Joanne M" sort="Jordan, Joanne M" uniqKey="Jordan J" first="Joanne M." last="Jordan">Joanne M. Jordan</name>
</author>
<author>
<name sortKey="Katz, Jeffrey N" sort="Katz, Jeffrey N" uniqKey="Katz J" first="Jeffrey N." last="Katz">Jeffrey N. Katz</name>
</author>
<author>
<name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name>
</author>
<author>
<name sortKey="Mahomed, Nizar" sort="Mahomed, Nizar" uniqKey="Mahomed N" first="Nizar" last="Mahomed">Nizar Mahomed</name>
</author>
<author>
<name sortKey="Pavelka, Karel" sort="Pavelka, Karel" uniqKey="Pavelka K" first="Karel" last="Pavelka">Karel Pavelka</name>
</author>
<author>
<name sortKey="Roos, Ewa M" sort="Roos, Ewa M" uniqKey="Roos E" first="Ewa M." last="Roos">Ewa M. Roos</name>
</author>
<author>
<name sortKey="Suarez Almazor, Maria E" sort="Suarez Almazor, Maria E" uniqKey="Suarez Almazor M" first="Maria E." last="Suarez-Almazor">Maria E. Suarez-Almazor</name>
</author>
<author>
<name sortKey="Zanoli, Gustavo" sort="Zanoli, Gustavo" uniqKey="Zanoli G" first="Gustavo" last="Zanoli">Gustavo Zanoli</name>
</author>
<author>
<name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
</author>
</analytic>
<series>
<title level="j" type="main">Journal of rheumatology</title>
<title level="j" type="abbreviated">J. rheumatol.</title>
<idno type="ISSN">0315-162X</idno>
<imprint>
<date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">Journal of rheumatology</title>
<title level="j" type="abbreviated">J. rheumatol.</title>
<idno type="ISSN">0315-162X</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Hip</term>
<term>Hip joint</term>
<term>Hip prosthesis</term>
<term>Indication</term>
<term>Joint space</term>
<term>Knee</term>
<term>Knee osteoarthritis</term>
<term>Ontario</term>
<term>Orthopedic surgery</term>
<term>Osteoarthritis</term>
<term>Pain</term>
<term>Prognosis</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Indication</term>
<term>Articulation coxofémorale</term>
<term>Hanche</term>
<term>Genou</term>
<term>Arthrose</term>
<term>Douleur</term>
<term>Pronostic</term>
<term>Ontario</term>
<term>Chirurgie orthopédique</term>
<term>Traitement</term>
<term>Coxarthrose</term>
<term>Prothèse de hanche</term>
<term>Gonarthrose</term>
<term>Interligne articulaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Objective. Time to theoretical indication of joint replacement surgery has been proposed as a primary outcome for potential structure-modifying interventions for osteoarthritis (OA). The objectives of this OMERACT/OARSI Working Group were to identify pain, physical function, and structure states that represent the progression from early to late disease for individuals with OA of the hip and knee, and to create a composite measure of these 3 domains to define states of OA severity and a surrogate measure of "need for joint replacement surgery." Methods. For pain, focus groups and one-on-one interviews were used. For function, Rasch analysis was performed on existing indices - the Hip Dysfunction and Osteoarthritis Outcome Score (HOOS) and the Knee injury and Osteoarthritis Outcome Score (KOOS), each of which subsumes the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questions. For structure, a comparison of existing indices (Kellgren-Lawrence, OARSI stages, and joint space width) was performed for the hip and the knee. Results. For pain, key features of pain that are most distressing to people with OA from early to late disease were identified. For function, the reduction of the number of items based on the existing indices continues. For structure, the analysis is also ongoing. Conclusion. Preliminary results were presented at OMERACT 8; the final objective will be to combine the 3 domains (pain, function, and structure) and to create a composite index that could define states of severity and "need for total joint replacement," which could be used to evaluate treatment response to disease-modifying drugs in OA clinical trials.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>République tchèque</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region>
<li>Angleterre</li>
<li>Bohême centrale</li>
<li>Bourgogne</li>
<li>Bourgogne-Franche-Comté</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Nouvelle-Galles du Sud</li>
<li>Ontario</li>
<li>Texas</li>
<li>Yorkshire-et-Humber</li>
<li>Île-de-France</li>
</region>
<settlement>
<li>Dijon</li>
<li>Leeds</li>
<li>Paris</li>
<li>Prague</li>
<li>Sydney</li>
<li>Toronto</li>
</settlement>
<orgName>
<li>Université de Leeds</li>
<li>Université de Sydney</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree>
<noCountry>
<name sortKey="Altman, Roy" sort="Altman, Roy" uniqKey="Altman R" first="Roy" last="Altman">Roy Altman</name>
<name sortKey="Cibere, Jolanda" sort="Cibere, Jolanda" uniqKey="Cibere J" first="Jolanda" last="Cibere">Jolanda Cibere</name>
<name sortKey="Conaghan, Philip G" sort="Conaghan, Philip G" uniqKey="Conaghan P" first="Philip G." last="Conaghan">Philip G. Conaghan</name>
<name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
<name sortKey="Hochberg, Marc C" sort="Hochberg, Marc C" uniqKey="Hochberg M" first="Marc C." last="Hochberg">Marc C. Hochberg</name>
<name sortKey="Jordan, Joanne M" sort="Jordan, Joanne M" uniqKey="Jordan J" first="Joanne M." last="Jordan">Joanne M. Jordan</name>
<name sortKey="Katz, Jeffrey N" sort="Katz, Jeffrey N" uniqKey="Katz J" first="Jeffrey N." last="Katz">Jeffrey N. Katz</name>
<name sortKey="Lohmander, L Stefan" sort="Lohmander, L Stefan" uniqKey="Lohmander L" first="L. Stefan" last="Lohmander">L. Stefan Lohmander</name>
<name sortKey="Mahomed, Nizar" sort="Mahomed, Nizar" uniqKey="Mahomed N" first="Nizar" last="Mahomed">Nizar Mahomed</name>
<name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name>
<name sortKey="Pavelka, Karel" sort="Pavelka, Karel" uniqKey="Pavelka K" first="Karel" last="Pavelka">Karel Pavelka</name>
<name sortKey="Roos, Ewa M" sort="Roos, Ewa M" uniqKey="Roos E" first="Ewa M." last="Roos">Ewa M. Roos</name>
<name sortKey="Suarez Almazor, Maria E" sort="Suarez Almazor, Maria E" uniqKey="Suarez Almazor M" first="Maria E." last="Suarez-Almazor">Maria E. Suarez-Almazor</name>
<name sortKey="Zanoli, Gustavo" sort="Zanoli, Gustavo" uniqKey="Zanoli G" first="Gustavo" last="Zanoli">Gustavo Zanoli</name>
</noCountry>
<country name="France">
<noRegion>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
</noRegion>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
<name sortKey="Hawker, Gillian" sort="Hawker, Gillian" uniqKey="Hawker G" first="Gillian" last="Hawker">Gillian Hawker</name>
<name sortKey="Maillefert, Jean Francis" sort="Maillefert, Jean Francis" uniqKey="Maillefert J" first="Jean Francis" last="Maillefert">Jean Francis Maillefert</name>
</country>
<country name="Canada">
<noRegion>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
</noRegion>
<name sortKey="Davis, Aileen M" sort="Davis, Aileen M" uniqKey="Davis A" first="Aileen M." last="Davis">Aileen M. Davis</name>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
<name sortKey="Hawker, Gillian" sort="Hawker, Gillian" uniqKey="Hawker G" first="Gillian" last="Hawker">Gillian Hawker</name>
</country>
<country name="Suède">
<noRegion>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
</noRegion>
</country>
<country name="États-Unis">
<region name="Californie">
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
</region>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
</country>
<country name="Royaume-Uni">
<region name="Angleterre">
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
</region>
</country>
<country name="Australie">
<region name="Nouvelle-Galles du Sud">
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
</region>
</country>
<country name="République tchèque">
<region name="Bohême centrale">
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
</region>
</country>
<country name="Italie">
<noRegion>
<name sortKey="Gossec, Laure" sort="Gossec, Laure" uniqKey="Gossec L" first="Laure" last="Gossec">Laure Gossec</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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